Family GP000446


Family ID GP000446  add to my list RDF
Family name 2-oxoacid dehydrogenase acyltransferase superfamily   suggest a name
Cross-reference(s) PMID:
Experimental analysis of the Arabidopsis mitochondrial proteome highlights signaling and regulatory components, provides assessment of targeting prediction programs, and indicates plant-specific mitochondrial proteins.
14671022 PMID:
Lipoic acid-dependent oxidative catabolism of alpha-keto acids in mitochondria provides evidence for branched-chain amino acid catabolism in Arabidopsis.
14764908 PMID:
Cloning and characterization of a dihydrolipoamide acetyltransferase (E2) subunit of the pyruvate dehydrogenase complex from Arabidopsis thaliana.
7890655 PMID:
Refined crystal structure of the catalytic domain of dihydrolipoyl transacetylase (E2p) from Azotobacter vinelandii at 2.6 A resolution.
8487300
Family Ontology
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molecular_function
dihydrolipoyllysine-residue succinyltransferase activity
GO:0004149 (17%) - dihydrolipoyllysine-residue succinyltransferase activity
cellular_component
oxoglutarate dehydrogenase complex
GO:0045252 (17%) - oxoglutarate dehydrogenase complex
pyruvate dehydrogenase complex
GO:0045254 (16%) - pyruvate dehydrogenase complex
Curation status ?
Found in No specificity
Phylogenetic analyzes Did not pass filtration




Clustering level Family ID (number of sequences)
1
2-oxoacid dehydrogenase acyltransferase superfamily
GP000446 (511)
2
Dihydrolipoamide acetyltransferase, long form family
GP015750 (375) , GP017124 (136)
3 GP041117 (185) , GP041766 (136) , GP041803 (126) , GP044058 (64)
4 GP070517 (185) , GP071179 (136) , GP071223 (126) , GP073445 (62)
Table 1: This table displays which relationship has the selected family with other families in GreenPhyl clustering ?.




Legend:
  • Families (clustering)
    • Sequences are clustered and classified at 4 levels (from less to more stringent).
    • The number between parenthesis indicates the number of sequences in the cluster.
    • Selected family is highlighted like this.
    • Annotated gene families are underlined and gene family name pops up when you move your mouse cursor over.
    • Gene families are coloured in this color when the phylogenetic analyses are available.


Sequence total: 511
Species Count (w/o splice) Count (w/ splice)
5 5
8 8
44 44
12 14
6 6
19 19
6 6
16 16
14 14
18 18
12 12
10 23
10 20
10 10
9 9
12 18
8 11
5 5
6 6
7 7
8 8
8 13
7 7
21 21
9 33
7 7
13 22
10 10
15 15
6 16
31 31
4 4
11 11
7 7
7 7
12 19
9 9


Information to display




(click on chart bars above to get species proteins)


Close InterPro family
IPR Annotation Type % Occurence Specificity
Dihydrolipoamide succinyltransferase
IPR006255
Dihydrolipoamide succinyltransferase Family 17 (89) Yes
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex
IPR006257
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex Family 16 (84) Yes

Close Other InterPro signatures
IPR Annotation Type % Occurence Specificity
Biotin/lipoyl attachment
IPR000089
Biotin/lipoyl attachment Domain 78 (397) No
2-oxoacid dehydrogenase acyltransferase, catalytic domain
IPR001078
2-oxoacid dehydrogenase acyltransferase, catalytic domain Domain 85 (432) No
2-oxo acid dehydrogenase, lipoyl-binding site
IPR003016
2-oxo acid dehydrogenase, lipoyl-binding site Binding_site 75 (384) No
E3 binding
IPR004167
E3 binding Domain 57 (293) No
Single hybrid motif
IPR011053
Single hybrid motif Domain 79 (404) No
Chloramphenicol acetyltransferase-like domain
IPR023213
Chloramphenicol acetyltransferase-like domain Domain 86 (437) No

Close Domain architecture
Clustering
 



Close Representative InterPro domains - Consensus schema
IPR023213 IPR000089 IPR011053 IPR001078 IPR003016 IPR004167


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Species
Information to display
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Alignment not available.
[Masking step 1 details] [Masking step 2 details] [Filtration details] [Global HMM file]

Phylogeny tree not available.


Alignment and filtration statistics:

Overall family sequences Sequences used for alignment (w/o splice) Sequences kept after filtration [min; median; max] ~average sequence length Alignment length Masked alignment length
511 422 (83%) 355 (69%) [40; 464; 1090] ~426 3013 225