Family GP000499


Family ID GP000499  add to my list RDF
Family name Thiamine pyrophosphate enzyme superfamily   suggest a name
Synonym(s) TPP vitamin B1
Cross-reference(s) PMID:
Crystal structure of the thiamin diphosphate-dependent enzyme pyruvate decarboxylase from the yeast Saccharomyces cerevisiae at 2.3 A resolution.
8604141
Family Ontology
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molecular_function
acetolactate synthase activity
GO:0003984 (15%) - acetolactate synthase activity
Curation status ?
Found in No specificity
Phylogenetic analyzes Did not pass filtration




Clustering level Family ID (number of sequences)
1
Thiamine pyrophosphate enzyme superfamily (plant-specificity: 50%)
GP000499 (469)
2
Pyruvate decarboxylase/indolepyruvate decarboxylase family
GP015902 (252) ,
Acetolactate synthase large subunit family
GP017750 (138) ,
(plant-specificity: 40%)
GP109094 (79) ,
(plant-specificity: 40%)
GP018799 (68) , GP029129 (4)
3 GP040582 (251) , GP042435 (136) , GP043560 (68) , GP125909 (4) , GP056215 (4)
4 GP070031 (251) , GP071993 (136) , GP073321 (68) , GP141200 (4) , GP088163 (4)
Table 1: This table displays which relationship has the selected family with other families in GreenPhyl clustering ?.




Legend:
  • Families (clustering)
    • Sequences are clustered and classified at 4 levels (from less to more stringent).
    • The number between parenthesis indicates the number of sequences in the cluster.
    • Selected family is highlighted like this.
    • Annotated gene families are underlined and gene family name pops up when you move your mouse cursor over.
    • Gene families are coloured in this color when the phylogenetic analyses are available.


Sequence total: 469
Species Count (w/o splice) Count (w/ splice)
2 2
3 3
18 18
10 13
13 13
27 27
13 13
13 13
12 12
26 26
11 11
17 20
6 7
7 7
6 6
17 20
6 6
7 7
8 8
9 9
18 18
6 6
6 6
10 10
9 17
9 9
12 18
10 10
11 11
8 8
41 41
11 11
17 17
9 9
7 7
20 23
7 7


Information to display




(click on chart bars above to get species proteins)


Close InterPro family
IPR Annotation Type % Occurence Specificity
Glyoxylate carboligase
IPR006397
Glyoxylate carboligase Family 1 (1) Yes
Thiamine pyrophosphate (TPP)-dependent enzyme
IPR012110
Thiamine pyrophosphate (TPP)-dependent enzyme Family 30 (141) Yes
Acetolactate synthase, large subunit, biosynthetic
IPR012846
Acetolactate synthase, large subunit, biosynthetic Family 15 (69) Yes
Hydroxypyruvate isomerase
IPR017643
Hydroxypyruvate isomerase Family 1 (1) Yes
Oxalyl-CoA decarboxylase
IPR017660
Oxalyl-CoA decarboxylase Family 1 (1) Yes
Hydroxypyruvate isomerase-like
IPR026040
Hydroxypyruvate isomerase-like Family 1 (2) Yes

Close Other InterPro signatures
IPR Annotation Type % Occurence Specificity
Thiamine pyrophosphate enzyme, C-terminal TPP-binding
IPR011766
Thiamine pyrophosphate enzyme, C-terminal TPP-binding Domain 67 (312) No
Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain
IPR012001
Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain Domain 69 (323) No

Close Domain architecture
Clustering
 



Close Representative InterPro domains - Consensus schema
Thiamine pyrophosphate enzyme, central domain
IPR012000 IPR012001 IPR011766



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Species
Information to display
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Alignment not available.
[Masking step 1 details] [Masking step 2 details] [Filtration details] [Global HMM file]

Phylogeny tree not available.


Alignment and filtration statistics:

Overall family sequences Sequences used for alignment (w/o splice) Sequences kept after filtration [min; median; max] ~average sequence length Alignment length Masked alignment length
469 442 (94%) 303 (65%) [46; 572; 1170] ~459 2935 199