Family GP000499


Family ID
GP000499  add to my list
Family name
Thiamine pyrophosphate enzyme superfamily   suggest a name
Synonym(s)
TPP vitamin B1
Cross-reference(s)
PMID:
Crystal structure of the thiamin diphosphate-dependent enzyme pyruvate decarboxylase from the yeast Saccharomyces cerevisiae at 2.3 A resolution.
8604141
Curation status ?
Taxonomic coverage
Magnoliopsida
Gene tree
Family level
1


(click on individual chart bar to display sequence composition below. Several bars can be selected and will remain highlighted)
Sequence total: 317
Species Sequence Count
6
4
2
5
8
4
3
3
7
4
6
2
5
2
6
17
4
6
6
5
6
4
3
9
10
7
4
4
26
5
8
11
9
4
9
12
3
7
23
4
4
5
5
8
15
7




Close InterPro family
IPR Annotation Type % Occurence Specificity
Thiamine pyrophosphate (TPP)-dependent enzyme
IPR012110 		Thiamine pyrophosphate (TPP)-dependent enzyme Family 50 (158) Yes
Indole-3-pyruvate decarboxylase, Enterobacteriaceae
IPR017764 		Indole-3-pyruvate decarboxylase, Enterobacteriaceae Family 1 (1) Yes

Close Other InterPro signatures
IPR Annotation Type % Occurence Specificity
Thiamine pyrophosphate enzyme, C-terminal TPP-binding
IPR011766 		Thiamine pyrophosphate enzyme, C-terminal TPP-binding Domain 57 (181) No
Thiamine pyrophosphate enzyme, central domain
IPR012000 		Thiamine pyrophosphate enzyme, central domain Domain 56 (177) No
Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain
IPR012001 		Thiamine pyrophosphate enzyme, N-terminal TPP-binding domain Domain 72 (229) No
DHS-like NAD/FAD-binding domain superfamily
IPR029035 		DHS-like NAD/FAD-binding domain superfamily Homologous_superfamily 62 (196) No
Thiamin diphosphate-binding fold
IPR029061 		Thiamin diphosphate-binding fold Homologous_superfamily 87 (276) No

Close Representative InterPro domains - Consensus schema
IPR029061 IPR029035 IPR012000 IPR012001 IPR012110 IPR011766

Close Domain architecture
Clustering





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